Invention Grant
- Patent Title: Compositions and methods directed to treating liver fibrosis
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Application No.: US15905229Application Date: 2018-02-26
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Publication No.: US10669303B2Publication Date: 2020-06-02
- Inventor: Gregory Hinkle , Victor Kotelianski , Brian Bettencourt , Alfica Sehgal , Tatiana Novobrantseva
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Nixon Peabody LLP
- Agent Mark J. FitzGerald; Ravinderjit Braich
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/02 ; C07K14/495 ; C07K14/78 ; C07K14/47
Abstract:
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-β, and SMAD2/3 genes, and methods of using such dsRNA compositions to inhibit expression of COL1A1, TGF-β, and SMAD2/3.
Public/Granted literature
- US20190016751A1 COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS Public/Granted day:2019-01-17
Information query
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