Invention Grant
- Patent Title: Mps1 and KNL1 phosphorylation system
-
Application No.: US15355824Application Date: 2016-11-18
-
Publication No.: US10669320B2Publication Date: 2020-06-02
- Inventor: Ajit P. Joglekar , Pavithra Aravamudhan
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- Agent David W. Staple
- Main IPC: C07K14/47
- IPC: C07K14/47 ; C12N9/12 ; A61K38/45
Abstract:
Provided herein are compositions and methods for the treatment of cancer by activating the spindle assembly checkpoint (SAC) in cells. In particular, dimerized Mps1 and Spc105/KNL1 constructs are provided as tunable activators of SAC, allowing for control of chromosome segregation accuracy and prevention of aneuploidies that are common in cancer.
Public/Granted literature
- US20170137478A1 ACTIVATING MITOTIC CHECKPOINT CONTROL MECHANISMS Public/Granted day:2017-05-18
Information query
