Blockade of RGMB for reducing transplantation-associated inflammation leading to loss of function of a transplanted organ in a graft recipient

Invention Grant

US10669335B2 Blockade of RGMB for reducing transplantation-associated inflammation leading to loss of function of a transplanted organ in a graft recipient 审中-公开

Patent Title: Blockade of RGMB for reducing transplantation-associated inflammation leading to loss of function of a transplanted organ in a graft recipient
Application No.: US16122369

Application Date: 2018-09-05
Publication No.: US10669335B2

Publication Date: 2020-06-02
Inventor: Everett Hurteau Meyer , Rosemarie H. Dekruyff , Panagiota Iliopoulou , Yuchiao Hsu , Magdiel Pérez Cruz
Applicant: The Board of Trustees of the Leland Stanford Junior University
Applicant Address: US CT Stanford
Assignee: The Board of Trustees of the Leland Stanford Junior University
Current Assignee: The Board of Trustees of the Leland Stanford Junior University
Current Assignee Address: US CT Stanford
Agency: Bozicevic, Field & Francis LLP
Agent Pamela J. Sherwood
Main IPC: C07K16/28
IPC: C07K16/28 ; C07K16/22 ; A61P37/06 ; A61K39/395 ; A61K39/00 ; A61K45/06

Abstract:

RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.

Public/Granted literature

Information query

Espacenet

IPC分类:

C	化学；冶金
C07	有机化学
C07K	肽（含有β-内酰胺的肽入C07D；在分子中除了形成本身的肽环外不含有任何其他的肽键的环状二肽，如哌嗪-2,5-二酮入C07D；环肽型麦角生物碱入C07D519/02；单细胞蛋白质、酶入C12N；获得肽的基因工程方法入C12N15/00）
C07K16/00	免疫球蛋白，例如，单克隆或多克隆抗体
C07K16/18	.抗来自动物或人的物质
C07K16/28	..抗受体，细胞表面抗原或细胞表面决定因子