A method for predictive open-loop and/or closed-loop control of an internal combustion engine with control variables pursuant to a model of the engine with characterizing variables and a control circuit for the control variables. The control variables are adjusted in an open-loop or closed-loop manner by measuring actual values and specifying target values of the characterizing variables and, optionally, depending on the boundary and/or environmental and/or ageing conditions. The characterizing variables are controlled pursuant to a model of the engine with the characterizing variables and a control circuit with the control variables. The controlling is part of a model-based predictive control, wherein the characterizing variables of the engine model are calculated and the control variables of the engine are adjusted in a predictively controlled manner. A model-based predictive non-linear controller is used for the controlling, which is constructed in a modular manner with a number of model-based predictive control modules.