A centrifugal compressor, in which a plurality of impellers that rotate along with a rotation shaft to pump fluid by using centrifugal force are disposed at a plurality of stages along an axial direction to compress, in a stepwise manner, the fluid sucked in from a suction port, the centrifugal compressor including: a closed impeller including a plurality of vanes disposed in a radial manner about the rotation shaft, and a shroud covering the plurality of vanes from radially outside; and an open impeller including a second plurality of vanes without a shroud. The closed impeller is disposed at a rearmost stage in a fluid flow direction. The open impeller is disposed at a stage located immediately after the suction port in the fluid flow direction.