Invention Grant
- Patent Title: System and method of label-free cytometry based on Brillouin light scattering
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Application No.: US16520134Application Date: 2019-07-23
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Publication No.: US10670511B2Publication Date: 2020-06-02
- Inventor: Giuliano Scarcelli , Jitao Zhang , Antonio Fiore , Hanyoup Kim
- Applicant: Canon U.S.A., Inc. , University of Maryland, College Park
- Applicant Address: US NY Melville US MD College Park
- Assignee: Canon U.S.A., Inc.,University of Maryland, College Park
- Current Assignee: Canon U.S.A., Inc.,University of Maryland, College Park
- Current Assignee Address: US NY Melville US MD College Park
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Main IPC: G01N21/00
- IPC: G01N21/00 ; G01N15/14 ; G01N15/00 ; G01N21/63 ; G01N15/10
Abstract:
The present invention relates to a method and system for a label-free cell analysis based on Brillouin light scattering techniques. Combined with microfluidic technologies according to the present invention, Brillouin spectroscopy constitutes a powerful tool to analyze physical properties of cells in a contactless non-disturbing manner. Specifically, subcellular mechanical information can be obtained by analyzing the Brillouin spectrum of a cell. Furthermore, a novel configuration of Brillouin spectroscopy is provided to enable simultaneous analysis of multiple points in a cell sample.
Public/Granted literature
- US20200018685A1 SYSTEM AND METHOD OF LABEL-FREE CYTOMETRY BASED ON BRILLOUIN LIGHT SCATTERING Public/Granted day:2020-01-16
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