An exemplary system, method and computer accessible medium for generating an image(s) of a portion(s) of a patient can be provided, which can include, for example, receiving first imaging information related to the portion(s), receiving second information related to modelling information of a further portion(s) of a further patient(s), where the modelling information includes (i) an under sampling procedure, and/or (ii) a learning-based procedure, and generating the image(s) using the first information and the second information. The modelling information can include artifacts present in a further image of the further portion(s). The image(s) can be generated by reducing or minimizing the artifacts. The second information can be generated, for example using a variational network(s).