The present disclosure discloses a transmission processing method and device. The transmission processing method includes: performing uplink scheduling for a User Equipment (UE) in accordance with an uplink scheduling criterion, and determining whether to apply puncturing in accordance with an uplink scheduling result and/or determining whether to instruct the UE to apply the puncturing via signaling in accordance with the uplink scheduling performed for the UE. The uplink scheduling criterion is preset and is for limiting the uplink scheduled UE to reduce a number of puncturing operations. In the prior art, an uplink scheduled UE that is transmitting data needs to be instructed to apply puncturing in a fixed position of a subframe whenever a new uplink scheduled UE appears in a wireless communication system, resulting in a technical problem of a low transmission rate, which is solved in the present disclosure.