Systems, methods, and circuitries enable selected signal components to be isolated in a feedback transmit signal that includes multiple signal components. In one example, a signal component cancellation system for a feedback receiver includes a transmit chain configured to transmit a transmit signal having at least two signal components with offset center frequencies. The system includes measurement circuitry configured to measure a received signal that results from feedback of the transmit signal and cancellation circuitry configured to cancel a selected signal component from the transmit signal to generate a cancellation signal. The system further includes subtraction circuitry configured to combine the cancellation signal with the measured received signal to generate a component signal corresponding to a contribution of the selected signal component to the received signal and provide the component signal to the feedback receiver.