Systems, methods, and apparatus for protected multi-operators payload operations are disclosed. In one or more embodiments, a disclosed method for protected multi-operators payload operations comprises transmitting, by a hosted payload (HoP) operation center (HOC), encrypted hosted commands to a host spacecraft operations center (SOC). Also, the method comprises transmitting, by the host SOC, encrypted host commands and the encrypted hosted commands to a vehicle. In addition, the method comprises reconfiguring a payload on the vehicle according to unencrypted host commands and unencrypted hosted commands. Additionally, the method comprises transmitting, by a payload antenna on the vehicle, payload data to a host receiving antenna and a hosted receiving antenna. Also, the method comprises transmitting, by a telemetry transmitter on the vehicle, encrypted host telemetry and encrypted hosted telemetry to the host SOC. Further, the method comprises transmitting, by the host SOC, the encrypted hosted telemetry to the HOC.