Clamping mechanisms that assist with the operation of small, portable x-ray devices are described. A support structure contains a clamping device for a portable X-ray device having a C-arm and a bottom containing a cradle configured to abut and support a C-arm of the portable x-ray device, a mounting plate configured to support a bottom portion of the portable x-ray device. The mounting plate has length members with ridges and a width member extending between the length members, a registration insert configured to mate with an opening in the portable x-ray device, and two clamps configured to secure the portable x-ray device to a cradle and the mounting plate. This clamping device allows the portable x-ray device to be quickly and easily attached to, and detached from, the support structure using only a single hand, while simultaneously preventing the portable x-ray device from accidentally being removed. Other embodiments are described.