This disclosure provides systems and methods for intravascular imaging. Some systems may be configured to generate a screening image of a section of a patient's vessel, identify one or more sub-sections of the screening image that each include a diagnostically significant characteristic of the vessel, and imaging the one or more sub-sections. Some systems may be configured to automatically identify the one or more sub-sections and/or to allow a user to manually identify the one or more sub-sections. Some systems may be configured to automatically image the one or more sub-sections after the one or more sub-sections are identified. In some examples, the system may be configured to displace blood during imaging of the sub-sections to enhance image quality. The system may be configured to minimize the period of time blood is displaced by synchronizing imaging and blood displacement.