A shaft assembly is disclosed which comprises an end effector configurable in an open configuration and a closed configuration, a closure system configured to transition the end effector toward the closed configuration during a closure stroke, a firing member movable through a firing stroke, and a frame. In various instances, the shaft assembly comprises a first bailout configured to shift the frame in order to open the end effector and a second, independent, bailout configured to retract the firing member during and/or after the firing stroke. In certain instances, the closure system is expandable to perform the closure stroke. In at least one such instance, the closure system comprises a proximal portion mounted to the frame and a distal portion movable relative to the proximal portion. In at least one instance, the firing member engages the closure member to expand the closure system.