A robot configured for mini-invasive surgery through a single parietal incision and/or natural orifice includes at least one articulated support, a stiffening component, and at least one maneuvering element. The articulated support includes a plurality of rigid bodies that are mutually associated. The stiffening component is associated with the articulated support and adapted for the transition of the articulated support from an inactive configuration, in which the rigid bodies can move with respect to each other, to an active configuration, in which the rigid bodies are mutually aligned so as to form a guide, and vice versa. The least one maneuvering element can be associated slidingly with the guide of the articulated body in its active configuration and can engage selectively a plurality of operating instruments accommodated in at least one container body that can be associated with the articulated support in its active configuration.