Invention Grant
- Patent Title: Salt derivative of tetrahydroisoquinoline and crystalline thereof and preparation method therefore and application thereof
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Application No.: US16329685Application Date: 2017-08-30
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Publication No.: US10676442B2Publication Date: 2020-06-09
- Inventor: Meihua Xie , Fuli Zhang , Taizhi Wu , Jialiang Zhong
- Applicant: CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRY , SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- Applicant Address: CN Pudong, New Area Shanghai CN Shanghai
- Assignee: China State Institute of Pharmaceutical Industry,Shanghai Institute of Pharmaceutical Industry
- Current Assignee: China State Institute of Pharmaceutical Industry,Shanghai Institute of Pharmaceutical Industry
- Current Assignee Address: CN Pudong, New Area Shanghai CN Shanghai
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@17ac1fb8 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@2851e4f4
- International Application: PCT/CN2017/099549 WO 20170830
- International Announcement: WO2018/041112 WO 20180308
- Main IPC: C07D217/18
- IPC: C07D217/18 ; A61P9/06 ; A61K31/472
Abstract:
The present invention discloses a salt derivative of 1-(3-methanesulfonamidobenzyl)-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline. The salt derivative has a solubility in water of not less than 3.0 nmol/mL or 1.8 mg/mL.The salt derivative has a solubility in water of not less than 3.0 nmol/mL or 1.8 mg/mL.
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