Invention Grant
- Patent Title: Antidiabetic bicyclic compounds
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Application No.: US16083677Application Date: 2017-03-24
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Publication No.: US10676458B2Publication Date: 2020-06-09
- Inventor: Michael Miller , Harry R. Chobanian
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merch Sharp & Dohne Corp. Rahway
- Current Assignee: Merch Sharp & Dohne Corp. Rahway
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2017/023939 WO 20170324
- International Announcement: WO2017/172505 WO 20171005
- Main IPC: C07D215/14
- IPC: C07D215/14 ; C07D401/04 ; C07D201/00 ; A61K31/47 ; A61K31/4709 ; A61K31/4725 ; A61K31/538 ; A61K45/06 ; C07D265/36 ; C07D413/04

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US20190071412A1 ANTIDIABETIC BICYCLIC COMPOUNDS Public/Granted day:2019-03-07
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