Invention Grant
- Patent Title: N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs as hedgehog pathway inhibitors and use thereof
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Application No.: US14415293Application Date: 2013-07-19
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Publication No.: US10676468B2Publication Date: 2020-06-09
- Inventor: Suixiong Cai , Ye Edward Tian , Sishun Kang , Zheng Meng , Chengyun Gu , Feng Yin , Shengzhi Chen , Yang Zhang , Xiuyan Zhang , Hongqiang Fei , Dongmei Wang
- Applicant: IMPACT Therapeutics, Inc.
- Applicant Address: CN Nanjing
- Assignee: Impact Therapeutics, Inc.
- Current Assignee: Impact Therapeutics, Inc.
- Current Assignee Address: CN Nanjing
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@728fe608 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@554ec262
- International Application: PCT/CN2013/079651 WO 20130719
- International Announcement: WO2014/012511 WO 20140123
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D401/10 ; C07D235/18 ; C07D403/10 ; C07D413/10 ; C07D409/04 ; C07D401/04 ; C07D487/04 ; C07D409/12 ; C07D401/14 ; C07D401/12 ; C07D471/04 ; C07D233/64 ; C07D213/40 ; C07D403/12 ; C07D413/12 ; C07D405/12 ; A61K31/4184 ; A61K31/454 ; A61K31/4725 ; A61K31/517 ; A61K31/536 ; A61K31/5377 ; A61K45/06
Abstract:
Disclosed are novel N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs thereof, represented by the Formula I: wherein C cyclic group, D1-D4, Q1, Q2, R5 are defined herein. Compounds having Formula (I) are hedgehog pathway inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of hedgehog activity, such as cancer.
Public/Granted literature
- US20150191460A1 N-(3-heteroarylaryl)-4-arylarylcarboxamides and Analogs as Hedgehog Pathway Inhibitors and Use Thereof Public/Granted day:2015-07-09
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