Invention Grant
- Patent Title: Method for developing lysine decarboxylase mutant and application thereof
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Application No.: US15746580Application Date: 2016-06-14
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Publication No.: US10676732B2Publication Date: 2020-06-09
- Inventor: Byung Gee Kim , Eun Young Hong
- Applicant: Seoul National University R&DB Foundation
- Applicant Address: KR Seoul
- Assignee: Seoul National University R&DB Foundation
- Current Assignee: Seoul National University R&DB Foundation
- Current Assignee Address: KR Seoul
- Agency: Stinson LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@29f7c9f4
- International Application: PCT/KR2016/006281 WO 20160614
- International Announcement: WO2017/022944 WO 20170209
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C12N1/21 ; C12P13/00 ; C12N15/60

Abstract:
The present invention relates to a method for producing a lysine carboxylase mutant strain, characteristics of the mutant strain, a gene encoding the lysine decarboxylase mutant strain, and a method for producing cadaverine using the same. The present invention provides lysine decarboxylase derived from E. coli improved through a protein engineering variation. In addition, the lysine decarboxylase mutant strain of the present invention increases activity, pH stability, and thermal stability at the time of producing cadaverine, thereby reducing production costs, through increasing a yield and productivity.
Public/Granted literature
- US20180291362A1 METHOD FOR DEVELOPING LYSINE DECARBOXYLASE MUTANT AND APPLICATION THEREOF Public/Granted day:2018-10-11
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