Invention Grant
- Patent Title: Targeted RNA editing
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Application No.: US15531164Application Date: 2015-12-17
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Publication No.: US10676737B2Publication Date: 2020-06-09
- Inventor: Bart Klein , Gerardus Johannes Platenburg
- Applicant: ProQR Therapeutics II B.V.
- Applicant Address: NL Leiden
- Assignee: ProQR Therapeutics II B.V.
- Current Assignee: ProQR Therapeutics II B.V.
- Current Assignee Address: NL Leiden
- Agency: Goodwin Procter LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@7b3d6ed1 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@58a93945 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@7875e82 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@10289fef
- International Application: PCT/EP2015/080347 WO 20151217
- International Announcement: WO2016/097212 WO 20160623
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; C12N15/90

Abstract:
RNA editing is achieved using oligonucleotide constructs comprising (i) a targeting portion specific for a target nucleic acid sequence to be edited and (ii) a recruiting portion capable of binding and recruiting a nucleic acid editing entity naturally present in the cell. The nucleic acid editing entity, such as ADAR, is redirected to a preselected target site by means of the targeting portion, thereby promoting editing of preselected nucleotide residues in a region of the target RNA which corresponds to the targeting portion.
Public/Granted literature
- US20190040383A1 TARGETED RNA EDITING Public/Granted day:2019-02-07
Information query
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