A method and apparatus for determining a route of a vehicle are provided. The method includes activating fail operative steering in response to detecting an electronic power steering (EPS) failure, determining a length of a lane map fusion ring, calculating a desired route based on a line of the lane map fusion ring if the determined length is greater than a first predetermined distance, and calculating desired route based on offset information and heading information of the lane map fusion ring and curvature information and curvature derivative information calculated from map data if the determined length is less than the first predetermined distance.