According to certain aspects, a method can include, at a first time, receiving an indication that a virtual machine (VM) residing on a source client computing device will be resumed, where a replicated version of the VM resides on the destination client computing device; performing a backup of first data associated with the replicated version of the VM residing on the destination client computing device; performing a backup of first memory associated with the replicated version of the VM residing on the destination client computing device; and transmitting the backup of the first data and the backup of the first memory for storage in one or more secondary storage devices.