Technologies for secure input/output device activation include a compute device to identify an attempt to activate an input/output device of the compute device, notify a controller of the compute device of the attempt to activate the input/output device via a communication channel that is out-of-band relative to an operating system of the compute device, determine whether to authorize activation of the input/output device based on a security policy, and allow the input/output device to resume activation in response to a determination that the security policy authorizes the activation. The security policy indicates whether one or more applications are authorized to access the input/output device.