A system and method for detecting tampering with a seal is provided. A loop seal tamper indicating device includes a seal wire that may be passed through a secured item or container to form a loop with the free ends of the seal wire passing through a seal housing. A plunger body including an adhesive-filled cavity is inserted into the seal housing, such that a piston expresses the adhesive into the space between the seal housing and the plunger body. The adhesive may contain reflective particles and is cured to fix the particles and the adhesive in place. A reference image may be taken to record the unique identifier and reflective signature of the adhesive. Future validation images may be compared to the reference image to determine whether the reflective signature has changed, thus indicating that the seal has been tampered with.