A method and system of transmitting a plurality of area-of-interest video codestreams is described. A first video codestream and one or more second video codestreams are generated from a plurality of large format images that are captured. The first video codestream has a first plurality of areas-of-interest selected from the plurality of large format images and the one or more second video codestream have at least a second plurality of areas-of-interest from the same plurality of large format images. The first video codestream is generated at a first frame rate and each of the second video codestreams is generated at a second frame rate. The first and second video codestreams are combined to obtain a combined video codestream. The combined video codestream is then transmitted to a computer system that regenerates the first video codestream and the one or more second video codestreams at their respective frame rates.