A head fixation device in the form of a skull clamp comprises an integrated rail for attaching accessories thereto. One or more clamps are configured to engage with the integrated rail. Additional accessories can be attached to the one or more clamps, which also include a starburst interface and an integrated rail. The clamps use a linear translating closure mechanism to engage the clamps to the integrated rail of the skull clamp. In some versions, the head fixation device is configured with a navigation adapter that attaches to an upper portion of the skull clamp.