The present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device comprising: an elongated main housing to accommodate a cartridge filled with the medicament and defining an axial direction, a piston rod arranged inside the main housing and extending in axial direction along a first axis to operably engage with a piston of the cartridge, a reset member axially displaceable inside the main housing between a proximal operating position and a distal reset position along a second axis radially offset from the first axis to switch the device between a reset mode and an operating mode, a cartridge holder releasably attachable to a distal end of the main housing on the first axis to accommodate a distal end of the cartridge, wherein the cartridge holder comprises a sidewall portion with a radially outwardly protruding lock member to axially engage with the reset member located radially adjacent the cartridge holder.