A vehicle brake system including a hydraulic brake device having two systems and configured to generate a braking force, wherein, in a failure condition of one of the two systems, one of the following two operation modes of the hydraulic brake device is selectively established: (a) a two-wheel mode in which master shut-off valves shut respective master fluid passages and a braking force that depends on a pressure of a working fluid supplied from a master cylinder is generated for each of right and left wheels; and (b) a one-wheel mode in which one of the master shut-off valves corresponding to the other of the two systems shuts off the corresponding master fluid passage and a braking force that depends on the working fluid supplied by a controlled-pressure supply device is generated for only one of the right and left wheels that corresponds to the other of the two systems.