Invention Grant
- Patent Title: Alpha-hemolysin variants with altered characteristics
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Application No.: US16375140Application Date: 2019-04-04
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Publication No.: US10683331B2Publication Date: 2020-06-16
- Inventor: Michael Dorwart , Daniel Korenblum
- Applicant: Roche Sequencing Solutions, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Fisherbroyles, LLP
- Agent Victoria L. Boyd; Jason M. Pass
- Main IPC: C07K14/31
- IPC: C07K14/31 ; C12Q1/6869
Abstract:
Described herein are variants of alpha-hemolysin having at least one mutation selected from T12R, T12K, N17R, N17K or combinations of T12 and N17 mutations. The variants in some embodiments may further comprise H144A. The α-hemolysin variants have a decreased time to thread.
Public/Granted literature
- US20190225656A1 ALPHA-HEMOLYSIN VARIANTS WITH ALTERED CHARACTERISTICS Public/Granted day:2019-07-25
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