Invention Grant
- Patent Title: Compounds inhibiting Nef-calnexin interaction
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Application No.: US16069483Application Date: 2017-01-12
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Publication No.: US10684274B2Publication Date: 2020-06-16
- Inventor: Alexei Adzhubei , Michael Bukrinsky , Ruth Hunegnaw
- Applicant: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION , Alexei Adzhubei
- Applicant Address: US DC Washington
- Assignee: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONLLY CHARTERED NOT-FOR-PROFIT CORPORATION
- Current Assignee: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONLLY CHARTERED NOT-FOR-PROFIT CORPORATION
- Current Assignee Address: US DC Washington
- Agency: Venable LLP
- Agent Miguel A. Lopez
- International Application: PCT/US2017/013236 WO 20170112
- International Announcement: WO2017/123795 WO 20170720
- Main IPC: G01N33/50
- IPC: G01N33/50 ; C07C223/06 ; C07D209/56 ; C07C381/00 ; A61K31/18 ; A61K31/167 ; A61K31/404
Abstract:
The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.
Public/Granted literature
- US20190033297A1 COMPOUNDS INHIBITING NEF-CALNEXIN INTERACTION Public/Granted day:2019-01-31
Information query
IPC分类:
