Interrupt rate determination can include instructions to determine a quantity of instances of packet processing by an operating system during a first period of time, each instance corresponding to a particular interrupt request sent by a device, determine a quantity of bytes processed during the first period of time by the operating system, determine a speed of the device, determine a first interrupt rate to assign to the device for a second period of time based on the quantity of instances, the quantity of bytes processed, and the speed of the device during the first period of time, and set the interrupt rate to the device.