A method for transmission and low-latency real-time output and/or processing of an audio data stream that is transmitted from at least one transmitter to at least one receiver over a jittering transmission path. The method includes a calibration for determining a distribution of latencies in transmission of packets of the audio data stream, whereby a group of packets of the audio data stream is used as calibration packets and wherein a reference time grid and an offset of a fastest calibration packet are determined. Then, a shift of an output time grid for audio output and/or processing, based on the reference time grid and the determined offset of the fastest calibration packet, and the audio packets of the audio data stream are provided according to the output time grid for audio output and/or processing.