Techniques for providing mobile device content delivery acceleration for mobile applications are discussed herein. Some embodiments may provide for a mobile accelerator system including a plurality of point-of-presences (POPs) and a control tower system. The control tower system may be configured to control mobile data transfer acceleration between a mobile device and the content server via the plurality of POPs of the mobile accelerator system. Each mobile application executing on the mobile device may be registered, validated, and then associated with a device POP that forms a dedicated connection with an entry POP of the plurality of POPs. Mobile data transfer acceleration for each mobile application may be selectively activated or deactivated, such as based on user configurations at the application level, domain name level, and/or country level.