A display panel cleaning machine is provided. The cleaning machine includes: a loading platform for loading a to-be-cleaned display panel, and an airflow mechanism disposed above the loading platform. The airflow mechanism includes ventilation ports disposed facing toward the loading platform. A baffle(s) is/are disposed outside the ventilation ports. Airflow flowing into and out from the airflow mechanism through the ventilation ports circulates along a predetermined direction and the display panel is cleaned in the circulation process.