A wheel retention system is provided for retaining a wheel on a vehicle. The system includes a plurality of connector receiving openings in a wheel hub flange, with each wheel hub flange including a raised bolt stop at each bolt receiving opening. A plurality of threaded connectors or bolts is provided, with each bolt received in one of the bolt receiving openings. Each bolt has a head with a flattened or clipped surface that meshes with the raised bolt stop in each bolt receiving opening on the wheel hub flange. These raised bolt stops positively prevent the bolts from rotating in the openings.