Invention Grant
- Patent Title: Method for producing intermediate of biotin and method for producing biotin
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Application No.: US16322511Application Date: 2017-07-26
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Publication No.: US10689349B2Publication Date: 2020-06-23
- Inventor: Fumiaki Iwasaki , Hiromasa Yamamoto , Kenji Tanaka , Masahiko Seki , Yoshiki Seike
- Applicant: Tokuyama Corporation
- Applicant Address: JP Yamaguchi
- Assignee: Tokuyama Corporation
- Current Assignee: Tokuyama Corporation
- Current Assignee Address: JP Yamaguchi
- Agency: Cahn & Samuels, LLP.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@bf9c048 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@494e1827 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@1ea8bd7c
- International Application: PCT/JP2017/027069 WO 20170726
- International Announcement: WO2018/025722 WO 20180208
- Main IPC: C07D233/34
- IPC: C07D233/34 ; C07D487/04 ; C07D491/048 ; C07D495/04

Abstract:
In the method, a trione compound represented by the following formula (1) is (i) reduced by NaAlH2(OCH2CH2OCH3)2 and subsequently further reduced by a metal borohydride salt, or (ii) reduced by calcium borohydride, thereby producing an amide alcohol compound represented by the following formula (3) (wherein, R1 and R2 may be the same or different and each represents a hydrogen atom or a protecting group of an ureylene group; R4 represents an alkyl group, an aralkyl group, or an aryl group; and each of R5, R6, and R7 represents a hydrogen atom, an alkyl group, an alkoxy group, or a halogen atom).
Public/Granted literature
- US20190382352A1 Method for Producing Intermediate of Biotin and Method for Producing Biotin Public/Granted day:2019-12-19
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