Invention Grant
- Patent Title: Assays for determining levels of plasma protease C1 inhibitor
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Application No.: US14761671Application Date: 2014-01-17
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Publication No.: US10690670B2Publication Date: 2020-06-23
- Inventor: Kusumam Joseph , Allen P. Kaplan
- Applicant: Dyax Corp.
- Applicant Address: US MA Lexington
- Assignee: Dyax Corp.
- Current Assignee: Dyax Corp.
- Current Assignee Address: US MA Lexington
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2014/012090 WO 20140117
- International Announcement: WO2014/113701 WO 20140724
- Main IPC: G01N33/573
- IPC: G01N33/573 ; C12Q1/37 ; G01N33/68 ; C07K16/38 ; C07K14/435 ; C07K16/40
Abstract:
The invention provides assay methods of detecting plasma protease CI inhibitor (Cl-INH) that binds plasma kallikrein, Factor XII, or both, and uses thereof for identifying subjects at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment.
Public/Granted literature
- US20150362492A1 EVALUATION, ASSAYS AND TREATMENT OF PKAL-MEDIATED DISORDERS Public/Granted day:2015-12-17
Information query
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