In an example, an enclosure opener may comprise an external actuator disposed externally to a device enclosure and having a post that extends into the enclosure, and a first separator cam disposed within the enclosure. The first separator cam is be rotatably engaged with the post of the external actuator. Upon rotation of the post relative to the enclosure, the first separator cam is to rotate and engage with an internal surface of the enclosure such that the first separator cam exerts an opening force against the internal surface to cause the device enclosure to separate along a mating seam to open the enclosure.