The present disclosure is directed to systems and methods that include cache operation storage circuitry that selectively enables/disables the Cache Line Flush (CLFLUSH) operation. The cache operation storage circuitry may also selectively replace the CLFLUSH operation with one or more replacement operations that provide similar functionality but beneficially and advantageously prevent an attacker from placing processor cache circuitry in a known state during a timing-based, side channel attack such as Spectre or Meltdown. The cache operation storage circuitry includes model specific registers (MSRs) that contain information used to determine whether to enable/disable CLFLUSH functionality. The cache operation storage circuitry may include model specific registers (MSRs) that contain information used to select appropriate replacement operations such as Cache Line Demote (CLDEMOTE) and/or Cache Line Write Back (CLWB) to selectively replace CLFLUSH operations.