This disclosure is directed to avoiding redundant memory encryption in a cryptographic protection system. Data stored in a device may be protected using different encryption systems. Data associated with at least one trusted execution environment (TEE) may be encrypted using a first encryption system. Main memory in the device may comprise data important to maintaining the integrity of an operating system (OS), etc. and may be encrypted using a second encryption system. Data may also be placed into a memory location via direct memory access (DMA) and may be protected utilizing a third encryption system. Redundant encryption may be avoided by encryption circuitry capable of determining when data is already protected by encryption provided by another system. For example, the encryption circuitry may comprise encryption control circuitry that monitors indicators set at different points during data handling, and may bypass certain data encryption or decryption operations based on the indicator settings.