A drive circuit, a display panel, a display device and a drive method. The drive circuit includes a plurality of shift registers; a first switch circuit connected with the shift registers, which is configured to selectively output output signals of the shift registers or a first voltage based on a first control signal and a second control signal; and a second switch circuit connected with the shift registers, which is configured to selectively output the output signals of the shift registers or the first voltage based on a third control signal and a fourth control signal. A set of shift registers can simultaneously or individually drive two display regions.