Methods and apparatus associated with predicting colorectal cancer tumor invasiveness are described. One example apparatus includes a set of circuits, and a data store that stores radiological images of tissue demonstrating colorectal cancer. The set of circuits includes a circumferential resection margin (CRM) prediction circuit that generates a CRM probability score for a diagnostic radiological image, an image acquisition circuit that acquires a diagnostic radiological image of a region of tissue demonstrating colorectal cancer pathology and that provides the diagnostic radiological image to the CRM prediction circuit, and a training circuit that trains the CRM prediction circuit to quantify chemoradiation response in the region of tissue represented in the diagnostic radiological image. The training circuit trains the CRM prediction circuit using a set of composite images.