- Patent Title: Transgenic mouse for the assessment of thyroid hormone (TH) action
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Application No.: US15531100Application Date: 2015-11-30
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Publication No.: US10694724B2Publication Date: 2020-06-30
- Inventor: Csaba Fekete , Balázs Gereben , Petra Mohácsik , Ferenc Erdélyi , Gábor Szabó
- Applicant: MAGYAR TUDOMÁNYOS AKADÉMIA KÍSÉRLETI ORVOSTUDOMÁNYI KUTATÓ INTÉZET
- Applicant Address: HU Budapest
- Assignee: Kisérleti Orvostudoányi Kutatóintézet
- Current Assignee: Kisérleti Orvostudoányi Kutatóintézet
- Current Assignee Address: HU Budapest
- Agent Jason D. Voight
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4ef1645c
- International Application: PCT/HU2015/050020 WO 20151130
- International Announcement: WO2016/083856 WO 20160602
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C12N15/00 ; C12N15/63 ; C07H21/04 ; C12N15/85 ; A61K49/00 ; C12Q1/6897 ; G01N33/50 ; G01N33/78
Abstract:
A transgenic animal model that is suitable for the cell or tissue specific assessing of thyroid hormone (TH) action in vivo is described. The recombinant DNA construct and methods suitable to generate such an animal are also provided. The assessment of TH action is based on a reporter that is dependent on an endogenously expressed thyroid hormone receptor (TR) and coregulators of said receptor.
Public/Granted literature
- US20170325429A1 TRANSGENIC MOUSE FOR THE ASSESSMENT OF THYROID HORMONE (TH) ACTION Public/Granted day:2017-11-16
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