An adapter for making a fluid connection between first and second medical fluid flow components, where the first component includes a first male or female Luer connector of a first configuration, and the component includes a second male female Luer connector of a second configuration, that is not compatible with the first configuration, includes a fluid flow conduit with a first adapter connector at a first end of the conduit and a second adapter connector at a second end of the conduit. The conduit includes a fluid flow lumen extending between the first and second ends. The first adapter connector is a male or female Luer having a first configuration that is compatible with the first medical fluid flow component connector. The second adapter connector is a male or female Luer having a second configuration that is compatible with the second medical fluid flow component connector.