A method of producing a three-dimensional shaped article includes a step of forming particle layers by arranging particles containing a material for forming a shaped article and particles containing a material having higher solubility in fluid than the material for forming the shaped article, a step of forming a stack by melting and stacking the particle layers, and a step of removing the material having higher solubility in the fluid than the material for forming the shaped article from the stack by dissolving the material having higher solubility in the fluid than the material for forming the shaped article in the fluid.