Provided is a high-voltage equipment cooling system for electric-powered vehicles, which is capable of cooling high-voltage equipment (an IPU herein) at an optimum air flow rate without impairing the air-conditioning state of a vehicle interior. This high-voltage equipment cooling system is equipped with an IPU cooling ECU with a control unit, which controls the air flow rate of an IPU fan on the basis of information related to the air blowing method for the IPU, information related to the air flow rate of a blower fan, information related to the selection of inside air circulation mode or outside air introduction mode by an HVAC, information related to the selection of one of air blowing modes by the HVAC, and information related to the air flow rate to be supplied to the IPU.