Invention Grant
- Patent Title: Enhancing activity of CAR T cells by co-introducing a bispecific antibody
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Application No.: US15690383Application Date: 2017-08-30
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Publication No.: US10696749B2Publication Date: 2020-06-30
- Inventor: Carl H. June , Yangbing Zhao , Xiaojun Liu
- Applicant: The Trustees of the University of Pennsylvania
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/46 ; C12N5/16 ; C12N15/62 ; A61K35/17 ; A61K47/68 ; A61K39/00
Abstract:
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof.
Public/Granted literature
- US20180057609A1 Enhancing Activity of CAR T Cells by Co-Introducing a Bispecific Antibody Public/Granted day:2018-03-01
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