- Patent Title: Ketoreductase polypeptides for the synthesis of chiral compounds
-
Application No.: US15543535Application Date: 2016-02-05
-
Publication No.: US10696953B2Publication Date: 2020-06-30
- Inventor: Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
- Applicant: Codexis, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- International Application: PCT/US2016/016692 WO 20160205
- International Announcement: WO2016/130412 WO 20160818
- Main IPC: C12N9/04
- IPC: C12N9/04 ; C12P41/00 ; C12P7/02 ; C12P17/12 ; C12P7/40
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Public/Granted literature
- US20180002676A1 KETOREDUCTASE POLYPEPTIDES FOR THE SYNTHESIS OF CHIRAL COMPOUNDS Public/Granted day:2018-01-04
Information query
