Invention Grant
- Patent Title: Nucleic acids encoding antibodies with high affinity for Alpha-Klotho
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Application No.: US16261141Application Date: 2019-01-29
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Publication No.: US10697963B2Publication Date: 2020-06-30
- Inventor: Sachdev S. Sidhu , Sarah L. Barker , Orson W. Moe , Makoto Kuro-o
- Applicant: The Governing Council of the University of Toronto , Board of Regents, The University of Texas System
- Applicant Address: CA Toronto US TX Austin
- Assignee: The Governing Council of the University of Toronto,Board of Regents, The University of Texas System
- Current Assignee: The Governing Council of the University of Toronto,Board of Regents, The University of Texas System
- Current Assignee Address: CA Toronto US TX Austin
- Agency: Fitch Even Tabin & Flannery LLP
- Main IPC: C12N9/24
- IPC: C12N9/24 ; G01N33/573 ; C07K16/28 ; G01N33/68 ; C07K14/71 ; C07K16/40
Abstract:
An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a αKlotho polypeptide, optionally a folded αKlotho or optionally with a dissociation constant (KD) of about 2 nM or less, as measured by competitive ELISA assay, methods of making and using to diagnose kidney diseases.
Public/Granted literature
- US20190145976A1 Antibodies With High Affinity For Alpha-Klotho Public/Granted day:2019-05-16
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