A calibration controller determines a latest arriving data strobe at a first data buffer in a read data path between at least one memory chip and a host on a high speed interface. The calibration controller aligns a chip clock distributed to a second data buffer in the read data path with the latest arriving data strobe, wherein data cross a first clock boundary from the first data buffer to the second data buffer, to minimize a latency in the read data path across the first clock boundary. The calibration controller aligns the chip clock with a high speed clock for controlling an unload pointer to unload the data from the second data buffer to a serializer in the read data path, wherein the data cross a second clock boundary from the second data buffer to the serializer, to minimize a latency in the read data path across a second clock boundary.