The present disclosure provides a capacitance detection circuit, which includes a front end circuit and a processing circuit; where the front end circuit comprises a first driving circuit, a first cancel circuit and a PGA circuit, the first driving circuit, the first cancel circuit and the PGA circuit are connected to a first end of a detection capacitor, a second end of the detection capacitor is grounded, and the processing circuit is connected to an output end of the front end circuit, and configured to determine a capacitance variation of a capacitance of the detection capacitor with respect to the base capacitance according to a voltage signal output by the front end circuit.